Phase 1 study of the safety, tolerability, and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies. [electronic resource]
Producer: 20110915Description: 2997-3004 p. digitalISSN:- 1557-3265
- Adult
- Aged
- Antineoplastic Agents -- administration & dosage
- Cell Hypoxia -- drug effects
- Disease Progression
- Dose-Response Relationship, Drug
- Female
- Humans
- Male
- Maximum Tolerated Dose
- Middle Aged
- Models, Biological
- Neoplasms -- drug therapy
- Nitroimidazoles -- administration & dosage
- Phosphoramide Mustards -- administration & dosage
- Prodrugs -- administration & dosage
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Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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