Targeted delivery of an antibody-mutant human endostatin fusion protein results in enhanced antitumor efficacy. [electronic resource]
Producer: 20110801Description: 603-14 p. digitalISSN:- 1538-8514
- Amino Acid Substitution
- Angiogenesis Inhibitors -- metabolism
- Animals
- Antibodies -- genetics
- Antineoplastic Agents -- metabolism
- Area Under Curve
- Cell Line
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Endostatins -- genetics
- Endothelial Cells -- drug effects
- Female
- Humans
- Mammary Neoplasms, Experimental -- drug therapy
- Mice
- Mice, Inbred BALB C
- Mice, SCID
- Mutant Proteins -- genetics
- Mutation
- Rabbits
- Receptor, ErbB-2 -- immunology
- Recombinant Fusion Proteins -- metabolism
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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