Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer. [electronic resource]
Producer: 20110913Description: 3186-97 p. digitalISSN:- 1476-5594
- Adult
- Aged
- Aged, 80 and over
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Breast Neoplasms -- drug therapy
- Cell Line, Tumor
- Cohort Studies
- Disease Progression
- Down-Regulation -- drug effects
- Estradiol -- pharmacology
- Estrogen Antagonists -- pharmacology
- Estrogens -- metabolism
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Middle Aged
- Proto-Oncogene Proteins -- genetics
- RNA, Messenger -- genetics
- Tamoxifen -- analogs & derivatives
- Transcription, Genetic -- drug effects
- Treatment Outcome
- Young Adult
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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