Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies. [electronic resource]
Producer: 20110527Description: 1271-9 p. digitalISSN:- 1527-7755
- Adolescent
- Adult
- Aged
- Angiogenesis Inhibitors -- adverse effects
- Apoptosis -- drug effects
- Aryl Hydrocarbon Hydroxylases -- genetics
- Biopsy
- Cytochrome P-450 CYP2C19
- Endothelial Cells -- drug effects
- England
- Female
- Focal Adhesion Kinase 1 -- metabolism
- Humans
- In Situ Nick-End Labeling
- Magnetic Resonance Imaging
- Male
- Maximum Tolerated Dose
- Middle Aged
- Neoplasms -- blood supply
- Neoplastic Cells, Circulating -- drug effects
- Neovascularization, Pathologic -- prevention & control
- Phosphorylation
- Polymorphism, Single Nucleotide
- Protein Kinase Inhibitors -- adverse effects
- Proto-Oncogene Proteins c-met -- antagonists & inhibitors
- Pyrrolidinones -- adverse effects
- Quinolines -- adverse effects
- Receptors, Growth Factor -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Treatment Outcome
- Young Adult
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Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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