Isatis indigotica induces hepatocellular cancer cell death via caspase-independent apoptosis-inducing factor translocation apoptotic pathway in vitro and in vivo. [electronic resource]
Producer: 20120416Description: 201-14 p. digitalISSN:- 1552-695X
- Animals
- Apoptosis -- drug effects
- Apoptosis Inducing Factor -- metabolism
- Body Weight -- drug effects
- Carcinoma, Hepatocellular -- drug therapy
- Caspase 3 -- metabolism
- Caspase 9 -- metabolism
- Caspase Inhibitors
- Caspases -- metabolism
- Cell Cycle -- drug effects
- Cell Line, Transformed
- Cell Line, Tumor
- Cell Nucleus -- drug effects
- Cell Survival -- drug effects
- Drugs, Chinese Herbal -- isolation & purification
- Eating -- drug effects
- Female
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Isatis -- chemistry
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Liver Neoplasms -- drug therapy
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Organ Size -- drug effects
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Tumor Suppressor Protein p53 -- metabolism
- Xenograft Model Antitumor Assays
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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