Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40. [electronic resource]
Producer: 20110606Description: 1116-23 p. digitalISSN:- 1873-2968
- Alkylating Agents -- pharmacology
- Amines -- chemistry
- Animals
- Aspartic Acid -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chromatography, High Pressure Liquid
- Cyclization
- Electrophoresis, Gel, Two-Dimensional
- Fluorescent Antibody Technique
- Glutamic Acid -- metabolism
- Melanoma, Experimental -- pathology
- Mice
- Prohibitins
- Repressor Proteins -- chemistry
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Tubulin -- chemistry
- Urea -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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