Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts. [electronic resource]
Producer: 20111014Description: 80-9 p. digitalISSN:- 1755-3245
- Analysis of Variance
- Angiotensin II -- administration & dosage
- Angiotensin II Type 1 Receptor Blockers -- pharmacology
- Animals
- Cell Adhesion Molecules -- genetics
- Cells, Cultured
- Cyclic AMP Response Element-Binding Protein -- metabolism
- DNA-Binding Proteins -- metabolism
- Fibroblasts -- drug effects
- Fibrosis
- Guanine Nucleotide Exchange Factors -- metabolism
- Infusions, Subcutaneous
- Losartan -- pharmacology
- Male
- Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors
- Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors
- Myocardium -- enzymology
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- RNA Interference
- RNA, Messenger -- metabolism
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
- Smad2 Protein -- metabolism
- Smad3 Protein -- metabolism
- Time Factors
- Transfection
- Transforming Growth Factor beta1 -- metabolism
- Up-Regulation
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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