Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma. [electronic resource]
Producer: 20111007Description: 3233-47 p. digitalISSN:- 1557-3265
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Apoptosis -- drug effects
- Brain Neoplasms -- drug therapy
- Chick Embryo
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Enzyme Activation -- genetics
- Furans -- administration & dosage
- Humans
- Mice
- Molecular Targeted Therapy
- Mutation -- physiology
- Neuroblastoma -- drug therapy
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase Inhibitors -- administration & dosage
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Pyridines -- administration & dosage
- Pyrimidines -- administration & dosage
- TNF-Related Apoptosis-Inducing Ligand -- administration & dosage
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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