Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors. [electronic resource]
Producer: 20110617Description: 1871-95 p. digitalISSN:- 1520-4804
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Crystallography, X-Ray
- Drug Screening Assays, Antitumor
- Indazoles -- chemical synthesis
- Mice
- Mice, SCID
- Models, Molecular
- Molecular Structure
- Morpholines -- chemical synthesis
- Neoplasm Transplantation
- Phosphorylation
- Piperidines -- chemical synthesis
- Protein Binding
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyrimidines -- chemical synthesis
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase
- Stereoisomerism
- Structure-Activity Relationship
- Transplantation, Heterologous
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Publication Type: Journal Article
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