Notch2/Hes-1 pathway plays an important role in renal ischemia and reperfusion injury-associated inflammation and apoptosis and the γ-secretase inhibitor DAPT has a nephroprotective effect. [electronic resource]
Producer: 20110616Description: 207-16 p. digitalISSN:- 1525-6049
- Acute Kidney Injury -- metabolism
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Animals
- Apoptosis -- drug effects
- Basic Helix-Loop-Helix Transcription Factors -- metabolism
- Cytokines -- metabolism
- Dipeptides -- pharmacology
- Epithelial Cells -- drug effects
- Homeodomain Proteins -- metabolism
- In Situ Nick-End Labeling
- Inflammation -- drug therapy
- Kidney -- drug effects
- Kidney Function Tests
- Male
- NF-kappa B -- metabolism
- Rats
- Rats, Sprague-Dawley
- Receptor, Notch2 -- metabolism
- Reperfusion Injury -- metabolism
- Signal Transduction
- Transcription Factor HES-1
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article
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