Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. [electronic resource]
Producer: 20110923Description: 1238-1248 p. digitalISSN:- 1872-6623
- Analgesics, Opioid -- therapeutic use
- Analysis of Variance
- Animals
- Benzamides -- therapeutic use
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Freund's Adjuvant -- adverse effects
- Ganglia, Spinal -- pathology
- Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacokinetics
- Inflammation -- chemically induced
- Mice
- Mice, Inbred C57BL
- Motor Activity -- drug effects
- NAV1.8 Voltage-Gated Sodium Channel
- Nociceptors -- drug effects
- Pain -- etiology
- Pain Measurement -- methods
- Piperazines -- therapeutic use
- Protein Binding -- drug effects
- Receptors, Opioid, delta -- deficiency
- Sodium Channels -- genetics
- Sulfur Isotopes -- pharmacokinetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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