Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins. [electronic resource]
Producer: 20110628Description: 12825-38 p. digitalISSN:- 1083-351X
- Cell Cycle Proteins -- genetics
- Cell Dedifferentiation
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival -- genetics
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor Proteins -- genetics
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- Heterochromatin -- genetics
- Humans
- Mutation, Missense
- Myeloid Cell Leukemia Sequence 1 Protein
- Oncogene Protein p21(ras) -- genetics
- Protein Serine-Threonine Kinases -- genetics
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins B-raf -- genetics
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Signal Transduction -- genetics
- Time Factors
- Transcription, Genetic -- genetics
- Tumor Suppressor Protein p53 -- genetics
- Up-Regulation -- genetics
- bcl-X Protein -- genetics
- cdc25 Phosphatases -- genetics
- Polo-Like Kinase 1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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