Treprostinil inhibits the adhesion and differentiation of fibrocytes via the cyclic adenosine monophosphate-dependent and Ras-proximate protein-dependent inactivation of extracellular regulated kinase. [electronic resource]
Producer: 20111115Description: 692-703 p. digitalISSN:- 1535-4989
- Cell Adhesion -- drug effects
- Cell Differentiation -- drug effects
- Cells, Cultured
- Cyclic AMP -- metabolism
- Cyclic AMP Response Element-Binding Protein -- metabolism
- Cyclic AMP-Dependent Protein Kinases -- metabolism
- Epoprostenol -- analogs & derivatives
- Extracellular Matrix -- metabolism
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Familial Primary Pulmonary Hypertension
- Humans
- Hypertension, Pulmonary -- enzymology
- Integrin alpha5 -- metabolism
- Integrin beta1 -- metabolism
- Leukocytes, Mononuclear -- drug effects
- Mutation
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-raf -- metabolism
- Receptors, Prostaglandin -- metabolism
- Signal Transduction -- drug effects
- Time Factors
- Transfection
- rap1 GTP-Binding Proteins -- genetics
- ras Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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