Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively. [electronic resource]
Producer: 20110214Description: 1173-9 p. digitalISSN:- 1550-6606
- Calcimycin -- pharmacology
- Calcium -- antagonists & inhibitors
- Calcium Channel Blockers -- pharmacology
- Catalysis -- drug effects
- Cell Line, Transformed
- Cell Line, Tumor
- Chromans -- metabolism
- Clone Cells
- Down-Regulation -- drug effects
- HL-60 Cells
- Humans
- Leukotriene Antagonists -- metabolism
- Leukotriene B4 -- antagonists & inhibitors
- Lipoxygenase Inhibitors -- pharmacology
- Neutrophil Activation -- drug effects
- Neutrophils -- drug effects
- Vitamin E -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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