The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. [electronic resource]
Producer: 20110404Description: 6060-70 p. digitalISSN:- 1557-3265
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Basic Helix-Loop-Helix Transcription Factors -- metabolism
- Brain Neoplasms -- drug therapy
- Cell Line, Tumor
- Cyclic S-Oxides -- administration & dosage
- Drug Evaluation, Preclinical
- Drug Resistance, Neoplasm -- genetics
- Gene Expression Regulation, Neoplastic
- Glioblastoma -- drug therapy
- Hedgehog Proteins -- genetics
- Homeodomain Proteins -- metabolism
- Humans
- Receptors, Notch -- metabolism
- Signal Transduction -- genetics
- Thiadiazoles -- administration & dosage
- Transcription Factor HES-1
- Transcription Factors -- genetics
- U937 Cells
- Veratrum Alkaloids -- administration & dosage
- Zinc Finger Protein GLI1
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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