Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. [electronic resource]
Producer: 20110209Description: 17068-78 p. digitalISSN:- 1529-2401
- Age Factors
- Amnesia -- pathology
- Animals
- Cell Culture Techniques
- Dendritic Spines -- pathology
- Hippocampus -- metabolism
- Lipid Metabolism -- genetics
- Low Density Lipoprotein Receptor-Related Protein-1 -- genetics
- Mice
- Mice, Knockout
- Nerve Degeneration -- genetics
- Neurons -- metabolism
- Prosencephalon -- metabolism
- Receptors, AMPA -- biosynthesis
- Receptors, N-Methyl-D-Aspartate -- biosynthesis
- Synapses -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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