Engineering kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variant. [electronic resource]
Producer: 20110324Description: 4329-40 p. digitalISSN:- 1083-351X
- Amino Acid Substitution
- Animals
- Antifibrinolytic Agents -- chemistry
- Aprotinin -- chemistry
- Blood Coagulation Factors -- chemistry
- Disease Models, Animal
- Escherichia coli
- Fibrinolysis -- drug effects
- Glycoproteins -- chemistry
- Hemorrhage -- drug therapy
- Humans
- Mice
- Mutation, Missense
- Protein Folding
- Protein Structure, Tertiary
- Recombinant Proteins -- chemistry
- Structure-Activity Relationship
- Tranexamic Acid -- chemistry
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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