Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism. [electronic resource]
Producer: 20110315Description: G241-52 p. digitalISSN:- 1522-1547
- Acetylcholine -- metabolism
- Animals
- Cholinergic Agonists -- metabolism
- Colon -- innervation
- Female
- Ganglia -- physiopathology
- In Vitro Techniques
- Interleukin-1beta -- pharmacology
- Interleukin-6 -- blood
- Interleukin-8 -- pharmacology
- Irritable Bowel Syndrome -- etiology
- Male
- Maternal Deprivation
- Mitogen-Activated Protein Kinases -- metabolism
- NF-kappa B -- metabolism
- Neurons -- drug effects
- Rats
- Rats, Sprague-Dawley
- Receptors, Interleukin-6 -- metabolism
- Recombinant Proteins -- pharmacology
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Submucous Plexus -- physiopathology
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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