Etanercept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats. [electronic resource]
Producer: 20110228Description: 454-9 p. digitalISSN:- 1526-7598
- Analgesics, Opioid -- administration & dosage
- Animals
- Anti-Inflammatory Agents -- administration & dosage
- Behavior, Animal
- Drug Tolerance
- Etanercept
- Gene Expression Regulation
- Immunoglobulin G -- administration & dosage
- Immunohistochemistry
- Inflammation -- chemically induced
- Inflammation Mediators -- antagonists & inhibitors
- Infusion Pumps
- Infusions, Parenteral
- Injections, Spinal
- Interleukin-1beta -- genetics
- Interleukin-6 -- genetics
- Male
- Microglia -- drug effects
- Morphine -- administration & dosage
- Pain Threshold -- drug effects
- RNA, Messenger -- metabolism
- Rats
- Rats, Wistar
- Reaction Time
- Receptors, Tumor Necrosis Factor -- administration & dosage
- Reverse Transcriptase Polymerase Chain Reaction
- Spinal Cord -- drug effects
- Time Factors
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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