Temporally resolved cAMP monitoring in endothelial cells uncovers a thrombin-induced [cAMP] elevation mediated via the Ca²+-dependent production of prostacyclin. [electronic resource]
Producer: 20110422Description: 181-93 p. digitalISSN:- 1469-7793
- Biosensing Techniques
- Calcium -- metabolism
- Capillary Permeability
- Cells, Cultured
- Cyclic AMP -- metabolism
- Endothelial Cells -- metabolism
- Epoprostenol -- metabolism
- Fluorescence Resonance Energy Transfer
- Humans
- Phospholipases A2 -- metabolism
- Prostaglandin-Endoperoxide Synthases -- metabolism
- Receptors, Epoprostenol
- Receptors, Prostaglandin -- metabolism
- Signal Transduction
- Thrombin -- metabolism
- Time Factors
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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