An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists. [electronic resource]
Producer: 20110623Description: 685-94 p. digitalISSN:- 1557-8127
- Analgesics -- pharmacology
- Animals
- Calcitonin Gene-Related Peptide -- metabolism
- Calcium Channel Blockers -- pharmacology
- Calcium Channels, N-Type -- metabolism
- Cell Line
- Ganglia, Spinal -- metabolism
- HEK293 Cells
- High-Throughput Screening Assays
- Humans
- Luminescent Measurements
- Neurons -- metabolism
- Pain -- physiopathology
- Patch-Clamp Techniques
- Presynaptic Terminals -- physiology
- Rats
- Small Molecule Libraries
- Spinal Cord -- metabolism
- omega-Conotoxins -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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