A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}. [electronic resource]
Producer: 20110209Description: 41863-73 p. digitalISSN:- 1083-351X
- Breast Neoplasms -- metabolism
- Butyrophenones -- chemistry
- Cell Line, Tumor
- Estrogen Receptor alpha -- antagonists & inhibitors
- Female
- Fluorescence Polarization
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- Humans
- Leupeptins -- pharmacology
- Models, Chemical
- Mucin-1 -- metabolism
- Proteasome Endopeptidase Complex -- metabolism
- Purines -- chemistry
- RNA, Messenger -- metabolism
- Response Elements
- Tamoxifen -- analogs & derivatives
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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