Bryostatin-1, a naturally occurring antineoplastic agent, acts as a Toll-like receptor 4 (TLR-4) ligand and induces unique cytokines and chemokines in dendritic cells. [electronic resource]
Producer: 20110131Description: 24-34 p. digitalISSN:- 1083-351X
- Animals
- Antineoplastic Agents -- metabolism
- Biological Products -- metabolism
- Bone Marrow Cells -- cytology
- Bryostatins -- metabolism
- Chemokines -- biosynthesis
- Dendritic Cells -- drug effects
- Female
- HEK293 Cells
- Humans
- Immunity, Innate -- drug effects
- Interferon Regulatory Factor-3 -- genetics
- Ligands
- Mice
- Myeloid Differentiation Factor 88 -- metabolism
- NF-kappa B -- antagonists & inhibitors
- Phenotype
- Protein Binding
- Toll-Like Receptor 4 -- metabolism
- Transcriptional Activation -- drug effects
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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