Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells. [electronic resource]
Producer: 20120611Description: 435-42 p. digitalISSN:- 1573-0646
- Acetylation
- Antineoplastic Agents -- pharmacology
- Cell Death -- drug effects
- Cell Line, Tumor
- Colorectal Neoplasms -- genetics
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- Dose-Response Relationship, Drug
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, Reporter
- Half-Life
- Histone Deacetylase Inhibitors -- pharmacology
- Histone Deacetylases -- metabolism
- Histones -- metabolism
- Humans
- Hydroxamic Acids -- pharmacology
- Lysine
- Male
- Mutation
- Naphthalenes -- pharmacology
- Prostatic Neoplasms -- genetics
- Protein Stability
- Proto-Oncogene Proteins c-mdm2 -- genetics
- Time Factors
- Transcriptional Activation -- drug effects
- Transfection
- Tumor Stem Cell Assay
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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