Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP×PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis. [electronic resource]
Producer: 20111122Description: 223-34 p. digitalISSN:- 1873-7064
- Adrenergic alpha-2 Receptor Antagonists -- administration & dosage
- Aging -- genetics
- Amyloid beta-Peptides -- biosynthesis
- Amyloid beta-Protein Precursor -- biosynthesis
- Animals
- Astrocytes -- drug effects
- Gliosis -- drug therapy
- Humans
- Longitudinal Studies
- Memory Disorders -- genetics
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Piperoxan -- administration & dosage
- Plaque, Amyloid -- drug therapy
- Presenilin-1 -- biosynthesis
- Pyrroles -- administration & dosage
- Receptors, Adrenergic, alpha-2 -- physiology
- Treatment Outcome
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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