Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation. [electronic resource]
Producer: 20110405Description: 237-54 p. digitalISSN:- 1476-5381
- Animals
- Anticarcinogenic Agents -- pharmacology
- Blotting, Western
- Down-Regulation -- drug effects
- Electrophoretic Mobility Shift Assay
- Hydroxybenzoates -- pharmacology
- Immunoprecipitation
- Matrix Metalloproteinase 2 -- biosynthesis
- Melanoma, Experimental -- enzymology
- Mice
- NF-kappa B -- metabolism
- Neoplasm Metastasis -- prevention & control
- Proto-Oncogene Proteins c-akt -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- ras Proteins -- metabolism
- rhoB GTP-Binding Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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