Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway. [electronic resource]
Producer: 20110106Description: 821-6 p. digitalISSN:- 1096-9098
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Benzenesulfonates -- pharmacology
- Blotting, Western
- Bone Neoplasms -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chondrosarcoma -- drug therapy
- Cyclin D1 -- metabolism
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Humans
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Pyridines -- pharmacology
- Signal Transduction -- drug effects
- Sorafenib
- raf Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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