Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition. [electronic resource]
Producer: 20110111Description: 6557-68 p. digitalISSN:- 1476-5594
- AMP-Activated Protein Kinases -- metabolism
- Aminoimidazole Carboxamide -- analogs & derivatives
- Antineoplastic Agents -- therapeutic use
- Antineoplastic Combined Chemotherapy Protocols
- Apoptosis -- drug effects
- Cell Line, Tumor
- Ceramides -- pharmacology
- Doxorubicin -- therapeutic use
- Drug Resistance, Neoplasm -- drug effects
- Humans
- Mechanistic Target of Rapamycin Complex 1
- Multiprotein Complexes
- Neoplasms -- drug therapy
- Proteins -- antagonists & inhibitors
- Reactive Oxygen Species -- metabolism
- Ribonucleotides -- pharmacology
- TOR Serine-Threonine Kinases
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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