PYDDT, a novel phase 2 enzymes inducer, activates Keap1-Nrf2 pathway via depleting the cellular level of glutathione. [electronic resource]
Producer: 20101020Description: 93-101 p. digitalISSN:- 1879-3169
- Adaptor Proteins, Signal Transducing -- biosynthesis
- Animals
- Cell Line, Tumor
- Cell Survival
- Cytoskeletal Proteins -- biosynthesis
- Drugs, Chinese Herbal -- chemistry
- Enzyme Induction
- Glutathione -- metabolism
- Hepatocytes -- drug effects
- Kelch-Like ECH-Associated Protein 1
- Metabolic Detoxication, Phase II
- Mice
- NF-E2-Related Factor 2 -- biosynthesis
- Oxidative Stress -- drug effects
- Plant Extracts -- pharmacology
- Plants, Medicinal -- chemistry
- Protein Processing, Post-Translational -- drug effects
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Thiophenes -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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