Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide. [electronic resource]
Producer: 20101207Description: 943-51 p. digitalISSN:- 1521-0111
- Antineoplastic Agents, Alkylating -- pharmacology
- Apoptosis
- Caspase 7 -- metabolism
- Cell Cycle Proteins -- genetics
- Cell Line, Transformed
- Cell Line, Tumor
- DNA Methylation
- Dacarbazine -- analogs & derivatives
- Drug Resistance, Neoplasm
- Fibroblasts -- drug effects
- Guanine -- analogs & derivatives
- Homozygote
- Humans
- Melanoma
- Methylnitronitrosoguanidine -- pharmacology
- Mutagens -- pharmacology
- Mutation
- Necrosis
- Nijmegen Breakage Syndrome -- pathology
- Nuclear Proteins -- genetics
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerases -- metabolism
- Temozolomide
- Uveal Neoplasms
- Uveal Melanoma
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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