The selective VEGFR1-3 inhibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts. [electronic resource]
Producer: 20110609Description: 2748-58 p. digitalISSN:- 1097-0215
- Animals
- Apoptosis
- Axitinib
- Blotting, Western
- Bone Marrow Neoplasms -- drug therapy
- Child
- Drug Synergism
- Endothelium, Vascular -- cytology
- Humans
- Imidazoles -- therapeutic use
- Indazoles -- therapeutic use
- Male
- Mice
- Mice, Nude
- Neovascularization, Pathologic -- drug therapy
- Neuroblastoma -- blood supply
- Phosphorylation
- Sirolimus -- pharmacology
- Stem Cells -- drug effects
- Tumor Cells, Cultured
- Vascular Endothelial Growth Factor Receptor-1 -- antagonists & inhibitors
- Vascular Endothelial Growth Factor Receptor-2 -- antagonists & inhibitors
- Vascular Endothelial Growth Factor Receptor-3 -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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