CP-690550, a Janus kinase inhibitor, suppresses CD4+ T-cell-mediated acute graft-versus-host disease by inhibiting the interferon-γ pathway. [electronic resource]
Producer: 20101116Description: 825-35 p. digitalISSN:- 1534-6080
- Animals
- Bone Marrow Cells -- cytology
- CD4-Positive T-Lymphocytes -- cytology
- Cell Differentiation -- drug effects
- Cytokines -- analysis
- Dendritic Cells -- cytology
- Graft vs Host Disease -- immunology
- Interferon-gamma -- antagonists & inhibitors
- Interleukin-2 -- immunology
- Janus Kinase 3 -- antagonists & inhibitors
- Lymphocyte Activation -- drug effects
- Lymphocyte Depletion
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Phosphorylation
- Piperidines
- Pyrimidines -- therapeutic use
- Pyrroles -- therapeutic use
- STAT3 Transcription Factor -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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