The nitric oxide-donating pravastatin, NCX 6550, inhibits cytokine release and NF-κB activation while enhancing PPARγ expression in human monocyte/macrophages. [electronic resource]
Producer: 20110314Description: 391-9 p. digitalISSN:- 1096-1186
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Cytokines -- metabolism
- Dose-Response Relationship, Drug
- Humans
- Interleukin-6 -- metabolism
- Macrophages -- cytology
- Mice
- Monocytes -- drug effects
- NF-kappa B -- antagonists & inhibitors
- Nitrates -- pharmacology
- Nitric Oxide -- metabolism
- Nitric Oxide Donors -- pharmacology
- PPAR gamma -- metabolism
- Pravastatin -- analogs & derivatives
- Superoxides -- metabolism
- Tumor Necrosis Factor-alpha -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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