The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. [electronic resource]
Producer: 20101221Description: 4262-73 p. digitalISSN:- 1528-0020
- AMP-Activated Protein Kinase Kinases
- Adaptor Proteins, Signal Transducing -- metabolism
- Animals
- Biocatalysis -- drug effects
- Cell Cycle Proteins
- Cell Death -- drug effects
- Cell Proliferation -- drug effects
- Enzyme Activation -- drug effects
- Hematopoietic Stem Cells -- cytology
- Humans
- Leukemia, Myeloid, Acute -- enzymology
- Metformin -- pharmacology
- Mice
- Neoplasm Proteins -- biosynthesis
- Phosphoproteins -- metabolism
- Phosphorylation -- drug effects
- Polyribosomes -- drug effects
- Protein Biosynthesis -- drug effects
- Protein Kinases -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- metabolism
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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