Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia. [electronic resource]
Producer: 20110215Description: 1252-62 p. digitalISSN:- 1748-7838
- Animals
- Becaplermin
- Carotid Arteries -- pathology
- Cell Movement
- Cell Proliferation
- Cyclin E -- metabolism
- Cyclin-Dependent Kinase 2 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Flavonoids -- pharmacology
- Hyperplasia -- prevention & control
- MAP Kinase Signaling System -- drug effects
- Male
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Muscle, Smooth, Vascular -- cytology
- Neointima -- etiology
- Platelet-Derived Growth Factor -- antagonists & inhibitors
- Proliferating Cell Nuclear Antigen -- metabolism
- Proto-Oncogene Proteins c-sis
- Rats
- Rats, Sprague-Dawley
- Receptor, Platelet-Derived Growth Factor beta -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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