The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic keratinocytes. [electronic resource]
Producer: 20100922Description: 2467-81 p. digitalISSN:- 1550-6606
- Binding Sites -- genetics
- Cells, Cultured
- Chromatin Immunoprecipitation
- DNA-Binding Proteins -- genetics
- Gene Expression Regulation -- drug effects
- Humans
- Immunoblotting
- Interferon Regulatory Factor-1 -- genetics
- Interferon-gamma -- pharmacology
- Keratinocytes -- drug effects
- Kruppel-Like Factor 4
- Kruppel-Like Transcription Factors -- genetics
- Luciferases -- genetics
- Promoter Regions, Genetic -- genetics
- Protein Binding -- drug effects
- Proto-Oncogene Proteins -- genetics
- Psoriasis -- genetics
- Repressor Proteins -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Sp1 Transcription Factor -- genetics
- Suppressor of Cytokine Signaling 1 Protein
- Suppressor of Cytokine Signaling Proteins -- genetics
- Time Factors
- Transfection
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Publication Type: Journal Article
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