Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. [electronic resource]
Producer: 20101216Description: 393-414 p. digitalISSN:- 1945-4589
- Caloric Restriction
- Cellular Senescence -- genetics
- Cyclic AMP-Dependent Protein Kinases -- physiology
- Humans
- Intracellular Signaling Peptides and Proteins -- physiology
- Lipid Metabolism -- genetics
- Lithocholic Acid -- physiology
- Longevity -- genetics
- Models, Genetic
- Saccharomyces cerevisiae Proteins -- physiology
- Sirolimus -- analysis
- Yeasts -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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