Tecarfarin, a novel vitamin K reductase antagonist, is not affected by CYP2C9 and CYP3A4 inhibition following concomitant administration of fluconazole in healthy participants. [electronic resource]
Producer: 20110714Description: 561-74 p. digitalISSN:- 1552-4604
- Administration, Oral
- Adult
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Benzoates -- administration & dosage
- Coumarins -- administration & dosage
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP3A
- Cytochrome P-450 CYP3A Inhibitors
- Drug Interactions
- Enzyme Inhibitors -- pharmacology
- Female
- Fluconazole -- pharmacology
- Humans
- Male
- NAD(P)H Dehydrogenase (Quinone) -- antagonists & inhibitors
- Warfarin -- administration & dosage
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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