A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model. [electronic resource]
Producer: 20101123Description: 319-326 p. digitalISSN:- 1872-6623
- Analysis of Variance
- Animals
- Bradykinin -- metabolism
- Calcitonin Gene-Related Peptide -- metabolism
- Glutamic Acid -- metabolism
- Osteoarthritis, Knee -- chemically induced
- Pain -- chemically induced
- Pain Measurement
- Rats
- Rats, Sprague-Dawley
- Spinal Cord -- drug effects
- Substance P -- metabolism
- TRPV Cation Channels -- antagonists & inhibitors
- Tetrahydronaphthalenes -- pharmacology
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Publication Type: Journal Article
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