Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists. [electronic resource]
Producer: 20110203Description: 366 p. digitalISSN:- 1471-2407
- Acetylation
- Apoptosis
- Azacitidine -- analogs & derivatives
- Biomarkers, Tumor -- genetics
- Blotting, Western
- Cell Proliferation
- Cells, Cultured
- Colorectal Neoplasms -- drug therapy
- CpG Islands
- DNA Methylation
- DNA Modification Methylases -- antagonists & inhibitors
- DNA, Neoplasm -- genetics
- Decitabine
- Enzyme Inhibitors -- pharmacology
- Epigenesis, Genetic
- Fibroblasts -- cytology
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic -- drug effects
- Genome, Human
- Histone Deacetylase Inhibitors -- pharmacology
- Histone Deacetylases -- chemistry
- Histones -- metabolism
- Humans
- Hydroxamic Acids -- pharmacology
- Immunoenzyme Techniques
- Oligonucleotide Array Sequence Analysis
- Promoter Regions, Genetic -- genetics
- RNA, Messenger -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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