Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models. [electronic resource]
Producer: 20101112Description: 1666-75 p. digitalISSN:- 1473-5598
- Animals
- Animals, Genetically Modified
- Antihypertensive Agents -- pharmacology
- Disease Models, Animal
- Disease Progression
- Dose-Response Relationship, Drug
- Guanylate Cyclase -- antagonists & inhibitors
- Heart -- drug effects
- Hypertension -- chemically induced
- Kidney -- drug effects
- Longevity -- drug effects
- Male
- Muscle Contraction -- drug effects
- Muscle, Smooth, Vascular -- drug effects
- Myocardium -- pathology
- NG-Nitroarginine Methyl Ester -- toxicity
- Nephrectomy
- Nephritis, Interstitial -- chemically induced
- Nitric Oxide -- metabolism
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Rabbits
- Rats
- Rats, Wistar
- Renin -- drug effects
- Signal Transduction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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