Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass. [electronic resource]
Producer: 20130529Description: 1596-607 p. digitalISSN:- 1543-8392
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- metabolism
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters -- metabolism
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Biological Availability
- Cytochrome P-450 CYP3A -- metabolism
- Humans
- Intestinal Absorption
- Intestine, Small -- metabolism
- Microsomes -- metabolism
- Middle Aged
- Models, Biological
- Neoplasm Proteins -- metabolism
- Pharmacokinetics
- Tissue Distribution
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Publication Type: Journal Article
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