1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity. [electronic resource]
Producer: 20100825Description: 5165-78 p. digitalISSN:- 1520-4804
- Administration, Topical
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- chemical synthesis
- Bile -- metabolism
- Biological Availability
- Blood Platelets -- drug effects
- Cytosol -- enzymology
- Dermatitis, Contact -- drug therapy
- Drug Stability
- Glucuronides -- metabolism
- Group IV Phospholipases A2 -- antagonists & inhibitors
- Humans
- Indoles -- chemical synthesis
- Mice
- Mice, Inbred C57BL
- Microsomes, Liver -- metabolism
- Phenyl Ethers -- chemical synthesis
- Rats
- Solubility
- Structure-Activity Relationship
- Thermodynamics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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