Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. [electronic resource]
Producer: 20100721Description: 1084-8 p. digitalISSN:- 1476-4687
- Animals
- Biocatalysis
- Cell Line
- Enzyme Activation
- Humans
- I-kappa B Kinase -- metabolism
- I-kappa B Proteins -- metabolism
- Lysine -- metabolism
- Lysophospholipids -- biosynthesis
- Mice
- Models, Molecular
- NF-KappaB Inhibitor alpha
- NF-kappa B -- metabolism
- Phosphorylation
- Phosphotransferases (Alcohol Group Acceptor) -- genetics
- Protein Binding
- Protein Structure, Tertiary
- Receptor-Interacting Protein Serine-Threonine Kinases -- metabolism
- Sphingosine -- analogs & derivatives
- Substrate Specificity
- TNF Receptor-Associated Factor 2 -- chemistry
- Tumor Necrosis Factor-alpha -- pharmacology
- Ubiquitin-Conjugating Enzymes -- metabolism
- Ubiquitin-Protein Ligases -- metabolism
- Ubiquitination -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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