Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V. [electronic resource]
Producer: 20110616Description: 220-34 p. digitalISSN:- 1099-1352
- Amino Acid Substitution
- Calorimetry
- Crystallography, X-Ray
- Cysteine -- genetics
- Diuretics -- metabolism
- Enzyme Activation
- Ethacrynic Acid -- metabolism
- Glutathione -- metabolism
- Glutathione S-Transferase pi -- chemistry
- Humans
- Hydrogen-Ion Concentration
- Kinetics
- Models, Molecular
- Mutant Proteins -- chemistry
- Mutation -- genetics
- Protein Multimerization
- Structure-Activity Relationship
- Substrate Specificity
- Thermodynamics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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