The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3beta pathway and beta-catenin stability. [electronic resource]
Producer: 20101206Description: 142 p. digitalISSN:- 1476-4598
- Anticarcinogenic Agents -- pharmacology
- Blotting, Western
- Bone Morphogenetic Protein 2 -- biosynthesis
- Cell Line, Tumor
- Fenretinide -- pharmacology
- Focal Adhesion Protein-Tyrosine Kinases -- metabolism
- Gene Silencing
- Glycogen Synthase Kinase 3 -- metabolism
- Glycogen Synthase Kinase 3 beta
- Humans
- Male
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Prostatic Neoplasms -- enzymology
- Proto-Oncogene Proteins c-akt -- metabolism
- beta Catenin -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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