Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation. [electronic resource]
Producer: 20110228Description: 4382-91 p. digitalISSN:- 1557-3265
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Arsenic Trioxide
- Arsenicals -- pharmacology
- Blotting, Western
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Enzyme Activation -- drug effects
- Female
- Humans
- JNK Mitogen-Activated Protein Kinases -- genetics
- Leukemia, Lymphocytic, Chronic, B-Cell -- metabolism
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Microscopy, Confocal
- Middle Aged
- Oxides -- pharmacology
- PTEN Phosphohydrolase -- metabolism
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- RNA Interference
- Signal Transduction -- drug effects
- Tumor Cells, Cultured
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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