PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. [electronic resource]
Producer: 20100809Description: 5457-64 p. digitalISSN:- 1538-7445
- Animals
- Antineoplastic Agents, Alkylating -- pharmacology
- Astrocytes -- drug effects
- Benzimidazoles -- pharmacology
- Brain Neoplasms -- drug therapy
- Cyclin-Dependent Kinase Inhibitor p16 -- deficiency
- DNA Damage
- DNA Repair
- Dacarbazine -- analogs & derivatives
- Glioblastoma -- drug therapy
- Methylnitronitrosoguanidine -- pharmacology
- Mice
- Mice, Transgenic
- PTEN Phosphohydrolase -- deficiency
- Poly(ADP-ribose) Polymerase Inhibitors
- Recombination, Genetic
- Temozolomide
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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