Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231. [electronic resource]
Producer: 20100721Description: 632-44 p. digitalISSN:- 1473-5741
- Anticarcinogenic Agents -- pharmacology
- Breast Neoplasms -- enzymology
- Carrier Proteins -- antagonists & inhibitors
- Catechin -- analogs & derivatives
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Survival -- drug effects
- Down-Regulation -- drug effects
- Extracellular Matrix Proteins -- metabolism
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Female
- Focal Adhesion Protein-Tyrosine Kinases -- metabolism
- Humans
- Matrix Metalloproteinase 9 -- metabolism
- NF-kappa B -- metabolism
- RNA, Messenger -- metabolism
- Signal Transduction -- drug effects
- Tissue Inhibitor of Metalloproteinase-1 -- metabolism
- Transcription Factor AP-1 -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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