Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease. [electronic resource]
Producer: 20100621Description: 7516-27 p. digitalISSN:- 1529-2401
- Alzheimer Disease -- complications
- Amyloid beta-Peptides -- administration & dosage
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Apoptosis -- genetics
- Brain -- pathology
- Cell Count -- methods
- Cell- and Tissue-Based Therapy -- methods
- Cells, Cultured
- Ciliary Neurotrophic Factor -- administration & dosage
- Disease Models, Animal
- Enzyme Inhibitors -- pharmacology
- Enzyme-Linked Immunosorbent Assay -- methods
- Gene Expression Regulation -- drug effects
- Green Fluorescent Proteins -- genetics
- Humans
- Male
- Maze Learning -- physiology
- Memory Disorders -- etiology
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation -- genetics
- Neurons -- drug effects
- Peptide Fragments -- administration & dosage
- Signal Transduction -- drug effects
- Synapses -- drug effects
- Synaptosomes -- metabolism
- Time Factors
- Transfection -- methods
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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